Dietary supplementation of Lactobacillus zeae regulated the gut microbiome in piglets infected with enterotoxigenic Escherichia coli

This study was conducted to investigate the effect of Lactobacillus zeae LB2 on gut microbiota in piglets infected with enterotoxigenic Escherichia coli (ETEC). Thirty-two healthy 7-day-old were randomly divided into four treatment groups: control group (basal diet), (supplemented 1 × 108 CFU/pig/day L. LB2), ETEC (infected 1010 ETEC) and ETEC+LB2 (LB2 supplementation + infection). Intestinal contents collected for DNA extraction Illumina sequencing. Significant result observed alpha diversity intestinal sections, both infection showed a higher Chao1 diversity. At phylum level, Firmicutes Bacteroidetes dominant piglets, while Proteobacteria ETEC-infected piglets. genus decreased abundance Prevotella, Ruminococcaceae, Lactobacillus, Alloprevotella, Flavobacterium, Sutterella increased Actinobacillus. The reduced Actinobacillus, Porphyromonas, Prevotella Lactobacillus. Both affected several functional pathways associated cellular processes, environmental information processing, genetic diseases, metabolism, organismal systems. In summary, induced dysbiosis microbiome could positively regulate during infection. Therefore, may be an ideal probiotic prevention or